Adults with migraine now have an additional preventative treatment option available to them, thanks to a new and unique migraine medication that has been approved by the Food and Drug Administration (FDA). Aimovig (erenumab-aooe) is a novel, first of its kind medication developed by Amgen Inc. that blocks the calcitonin gene-related peptide receptor (CGRP-R), which plays a significant role in migraine. In clinical trials, Aimovig demonstrated efficacy and consistency in reducing the number of monthly migraine days, with many patients experiencing a reduction of at least 50 percent (Amgen, 2018).
Aimovig was shown to be safe and effective in preventing migraine symptoms through several large global, randomized, double-blind, placebo-controlled studies, of which there were more than 2,000 patients who participated. Phase 2 and Phase 3 studies showed that Aimovig significantly reduced both the number of monthly migraine days and the use of acute migraine medicines, compared to placebo. In an ongoing open-label extension study, this lessening in the number of monthly migraine days has been shown to be sustained for a period of up to 15 months (Amgen, 2018). One study found that in patients who are difficult-to-treat – those who have had no success with up to four previous treatments – Aimovig demonstrated the ability to halve the number of monthly migraine days by greater odds compared to placebo. The medicine also has a strong safety profile; the most common side effects reported by patients in clinical trials were injection site reactions and constipation (Amgen, 2018)
Migraine is a serious and painful neurological disease that affects millions of Americans. It has a considerable impact on patients and can impede their abilities to function at work, social settings, and in other areas of their lives. Symptoms include a pulsating, throbbing pain on one side of the head, as well as nausea, dizziness, sensitivity to light and/or sound, and other painful/disruptive symptoms.
To learn more about current preventative migraine treatments, including what anti-CGRP monoclonal antibodies are, read our prior article on this topic.
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Amgen. (2018, May 17). FDA Approves Aimovig™ (erenumab-aooe), A Novel Treatment Developed Specifically For Migraine Prevention. Retrieved from https://www.prnewswire.com/news-releases/fda-approves-aimovig-erenumab-aooe-a-novel-treatment-developed-specifically-for-migraine-prevention-300650778.html